New Research Reveals TDP-43’s Role in RNA Processing Errors in Neurodegenerative Diseases
Scientists have discovered that TDP-43 protein loss impacts RNA processing beyond splicing errors. The findings reveal widespread changes in RNA endings that contribute to neurodegeneration in ALS and frontotemporal dementia.
Breakthrough Findings in Neurodegenerative Disease Research
New research has uncovered additional mechanisms through which TDP-43 protein dysfunction contributes to neurodegenerative diseases, according to recent studies published in Nature Neuroscience. The findings reveal that the protein’s role extends beyond previously known RNA splicing errors to affect how RNA molecules are processed at their endings, potentially explaining broader aspects of disease pathology in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).